张婷婷,1986年10月生,山西寿阳人,博士,www.winsb111.com,副教授,硕士研究生导师。
2005/09-2008/07,西北农林科技大学,生物工程专业,本科,学士。
2008/09-2013/12,西北农林科技大学,遗传学专业硕博连读,博士。
2013/12-至今,www.winsb111.com,讲师,副教授
主要研究方向:
昆虫胚胎几丁质发育;昆虫基因编辑;巴西苏木素抑制膀胱癌机理研究。
科研项目:
1. 飞蝗几丁质酶5两个亚型的基因编辑及功能研究,国家自然科学基金青年基金,2016.01-2018.12,20万元,在研,主持人。
2.c-Fos介导的巴西苏木素抑制膀胱癌T24细胞机理研究,山西省高校创新研究项目,2014.07-2016.12, 4万元,在研,主持人。
3. 苏复宁洗液抑制膀胱癌分子靶标及信号通路的研究与应用,山西省优秀人才专项,2016.06-2018.12,10万元,在研,主持人。
发表研究论文:
[1] ZhangTingting1,Fan xinping1,Song lili1,Zhang Shengwan,Ma Enbo,Ren Liansheng*,Zheng Yaowu*,Zhang Jianzhen*.c-Fos Is Involved in Inhibition of Human Bladder Carcinoma T24 Cells by Brazilin. IUBMB Life. 2015,67(3):175–181.(IF=2.35)
[2] K. Xu, T. Zhang, L. Guo, Y. Xin, L. Zhang, Z. Zhang*. Alternative methods for the efficient construction of short hairpin RNA expression vectors, Anal Biochem 478 (2015) 23-25.(IF=2.22,co-first authors)
[3] T. Zhang, L. Sun, Y. Xin, L. Ma, Y. Zhang, X. Wang, K. Xu, C. Ren, C. Zhang, Z. Chen, H. Yang, Z. Zhang*, A vaccine grade of yeast Saccharomyces cerevisiae expressing mammalian myostatin, BMC Biotechnol 12 (2012) 97.(IF=2.35)
[4] T. Zhang, H. Yang, R. Wang, K. Xu, Y. Xin, G. Ren, G. Zhou, C. Zhang, L. Wang, Z. Zhang*, Oral administration of myostatin-specific whole recombinant yeast Saccharomyces cerevisiae vaccine increases body weight and muscle composition in mice, Vaccine 29 (2011) 8412-8416.(IF=3.76)
[5] K. Xu, T.T. Zhang, L. Wang, C.F. Zhang, L. Zhang, L.X. Ma, Y. Xin, C.H. Ren, Z.Q. Zhang, Q. Yan, D. Martineau, Z.Y. Zhang*, Walleye dermal sarcoma virus: expression of a full-length clone or the rv-cyclin (orf a) gene is cytopathic to the host and human tumor cells, Mol Biol Rep 40 (2013) 1451-1461.(co-first authors, IF=2.929)
[6] L. Zhang, T. Zhang, L. Wang, S. Shao, Z. Chen, Z. Zhang*, In vivo targeted delivery of CD40 shRNA to mouse intestinal dendritic cells by oral administration of recombinant Sacchromyces cerevisiae, Gene Ther 21 (2014) 709-714.(IF=4.2)
[7] L. Wang, J. Lin, T. Zhang, K. Xu, C. Ren, Z. Zhang*, Simultaneous screening and validation of effective zinc finger nucleases in yeast, PLoS One 8 (2013) e64687.(IF=4.0)
[8] L. Wang, K. Xu, J. Lin, S. Shao, T. Zhang, H. Xu, Z. Wei, Z. Zhang*, A novel genetic system based on zinc finger nucleases for the identification of interactions between proteins in vivo, PLoS One 8 (2013) e85650. (IF=4.0)
[9] K. Xu, Z. Liu, L. Zhang, T. Zhang, Z. Zhang*, SiRNA In Vivo-Targeted Delivery to Murine Dendritic Cells by Oral Administration of Recombinant Yeast, Methods Mol Biol 1364 (2016) 165-181.
[10] K. Xu, C. Ren, Z. Liu, T. Zhang, T. Zhang, D. Li, L. Wang, Q. Yan, L. Guo, J. Shen, Z. Zhang*, Efficient genome engineering in eukaryotes using Cas9 from Streptococcus thermophilus, Cell Mol Life Sci 72 (2015) 383-399.(IF=5.8)
[11] C. Zhang, L. Wang, G. Ren, Z. Li, C. Ren, T. Zhang, K. Xu, Z. Zhang*, Targeted disruption of the sheep MSTN gene by engineered zinc-finger nucleases, Mol Biol Rep 41 (2014) 209-215.(IF=2.929)
[12] C. Zhang, K. Xu, L. Hu, L. Wang, T. Zhang, C. Ren, Z. Zhang*, A suicidal zinc finger nuclease expression coupled with a surrogate reporter for efficient genome engineering, Biotechnol Lett 37 (2015) 299-305.
[13] Z. Zhang, D. Li, H. Xu, Y. Xin, T. Zhang, L. Ma, X. Wang, Z. Chen, Z. Zhang*, A simple and efficient method for assembling TALE protein based on plasmid library, PLoS One 8 (2013) e66459.
[14] 张婷婷,柳伟伟,李涛,张敏,张学尧,马恩波,张建珍*. RNA靶向基因组编辑技术CRISPR/Cas9在昆虫中的研究进展,天津师范大学学报(自然科学版).(2015). 35 (3) :61-65.
[15] 张婷婷, 辛颖, 张志强, 任充华, 杨涵江, 王令, 张智英*. PiggyBac转座子介导的诱导细胞永生化转基因载体的构建及其整合效率的检测, 中国农业科学 (2012).
[16] 张婷婷, 周光现, 王昕, 张智英*. 人XIAP基因多克隆抗体的快速制备方法研究, 西北农林科技大学学报(自然科学版) (2011).
[17]任充华, 张婷婷, 杨涵江, 王昕, 陈知龙, 张智英*.人端粒酶逆转录酶(hTERT)基因腺病毒载体的构建及包装, 西北农林科技大学学报(自然科学版) (2012).
[18]宋丽丽,任璐,张婷婷,马恩波,郑耀武,任连生,张建珍*.GADD45β过表达抑制膀胱癌细胞T24的增殖, 山西大学学报(自然科学版),2014,37(4):625-629.
[19]任璐,宋丽丽,张婷婷,马恩波,郑耀武,任连生,张建珍*.HO-1超表达载体的构建及其对膀胱癌T24细胞的影响,山西大学学报(自然科学版), 2015,38(1):150-154.
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